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 Dupuytren s disease is a
benign proliferative disease occurring in
the palmar and digital fascia producing
nodules, cords & contractures. These
cause progressive flexion contractures of
the digits especially at
metacarpophalangeal and interphalangeal
joint level. The ring and little fingers
are most commonly affected. More
aggressive forms of the disease include
bilateral involvement, ectopic lesions
(penile fibromatosis Peyronie s disease,
and plantar fibromatosis Ledderhose
disease).
This disease is most commonly seen amongst
Caucasian males of northern European
ancestry. Associated links have been found
with diabetes, trauma, especially manual
vibration tool use, epilepsy and use of
antiepileptic drugs, autoimmune diseases,
HIV, smoking and alcoholic liver disease.
The incidence is high in the west but
sporadic cases have been reported from
Africa and Asia.
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